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Miami Transplant Institute

Miami Transplant Institute

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Clinical Research

Research in the Miami Transplant Institute includes basic laboratory and clinical research within our three main divisions: Kidney and Pancreas, Liver and Gastrointestinal and Heart and Lungs transplant.

The overall mission of our research is to study novel immunosuppressive treatments in order for our transplanted patients to attain a better quality of live after transplantation: reducing the side effects of medications, as well as reducing the incidence of transplant rejection after cadaveric or living-related donor transplants.

Clinical trials are organized within the other two groups under the direction of Dr. George Burke for the Kidney and Pancreas Program and Dr. Rodrigo Vianna for the Liver and GI program.

Our research is funded under different sources; institutional, government/agency and industry.

Heart and Lung Transplant

  • A Prospective Study Using Humanized Monoclonal Antibody against CD52 (Campath-1H) and Tacrolimus in Heart Transplant Recipients
    Protocol: FK-04-003
    Sponsor: Astellas Pharma US, Inc.
    Sponsor Group: Industry
    P.I: Si Pham, M.D.

Kidney and Pancreas Transplant

  • Assessment of Allograft Recipient Bone Marrow and Blood Cell Chimerism, Immune Reactivity and Regulatory Properties Following
    Transplantation and Bone Marrow Infusion.
    Protocol: 19950548
    Sponsor: Institution
    P.I.: George Burke, M.D.
  • Assessment of Simultaneous Pancreas/Kidney (SPK) Allografts Recipient Bone Marrow, Skin, and Blood Cell Chimerism, Immune Reactivity and Regulatory Properties Following Transplantation With of Without Donor Bone Marrow Infusion
    Protocol: 19960130
    Sponsor: Institution
    P.I.: George Burke, M.D.
  • Tacrolimus and Mycophenolate Mofetil vs Tacrolimus and Sirolimus in SPK, Pancreas after Kidney or Pancreas Transplant Alone
    Protocol: 20000176
    Sponsor: Institution
    P.I.: George Burke, M.D.
  • Pilot Study Using Donor Stem Cells and Campath-1H to Induce Renal Transplant Tolerance
    Protocol: Subcontract 3270 – N01-A1-15416 / 20030235
    Sponsor: Immune Tolerance Network (NIH)
    Sponsor Group: Government
    P.I.: George Burke, M.D.
  • Recurrence of T1D in Pancreas Transplantation
    Protocol: 5R01DK070011-04 / 20050510
    Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIH)
    Sponsor Group: Government
    P.I.: George Burke, M.D.
  • Solid Organ Transplant in HIV: Multi-Site Study
    Protocol: 20051311
    Sponsor: University of California San Francisco (NIH)
    Sponsor Group: Government
    P.I.: Jorge Diego, M.D.
  • A Phase II, Open-Label, Multicenter Study to Assess the Pharmacokinetics, Long-Term Safety and Tolerability of Tacrolimus in Stable Kidney Transplant Patients Converted from a Prograf Based Immunosuppression Regimen to a Modified Release (MR) Tacrolimus Based Immunosuppression Regimen
    Protocol: 20020507
    Sponsor: Astellas Pharma US, Inc.
    Sponsor Group: Industry
    P.I.: George Burke, M.D.
  • Randomized Trial of 2 Antibody Induction Steroid Avoidance Protocols Accompanied by Maintenance Therapy with Prograf and Myfortic
    Protocol: 20060047
    Sponsor: Novartis Pharmaceutical Corporation
    Sponsor Group: Industry
    P.I.: George Burke, M.D.
  • A Randomized, Placebo Controlled, Double-Blind Comparative Study Evaluating the Effect of Ramipril on Urinary Protein Excretion in Maintenance Renal Transplant Patients Converted to Sirolimus
    Protocol: 20070779
    Sponsor: Wyeth Pharmaceuticals
    Sponsor Group: Industry
    P.I.: George Burke, M.D.
  • Evaluation of Recipients with and without Proteinuria, Pre and Post Kidney
    Transplantation – FSGS
    Protocol: 20070206
    Sponsor: Institutional
    P.I.: George Burke, M.D.

Liver and Gastrointestinal Transplant

  • Solid Organ Transplant in HIV: Multi-Site Study
    Protocol: 20057647
    Sponsor: University of California San Francisco (NIH)
    Sponsor Group: government
Miami Transplant Institute
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